ORTHO-ALLO-UNION

ORTHOpaedic treatment with ALLOgenic combined ATMP in long bone fracture delayed UNION and non-union (ORTHO-ALLO-UNION).

Period: 01/12/2023 – 30/11/2028

Funding scheme: HORIZON-RIA – HORIZON Research and Innovation Actions

Coordination: Servicio Madrileno De Salud

Website:https://orthoallounion.eu

Abstract: Universal therapy for delayed healing in fractures

While only 5 % of long bone fractures result in non-union, this still poses a significant challenge due to the sheer number of new fractures each year and the increasing complexity of fractures, which heightens the risk of non-consolidation. Treatment options include bone autografts, autologous mesenchymal cells, or other interventions. The EU-funded ORTHO-ALLO-UNION project aims to develop a universal therapy for fractures that have experienced delayed or failed healing. Rather than reserving advanced therapy medicinal products (ATMPs) solely as a last resort for established non-union fractures, the project proposes that patients should receive combined ATMP treatment as soon as the need for reoperation is identified. This approach is in line with patients’ needs and aligns with widespread practice in the EU.