Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Period: 01/11/2021 – 31/10/2026
Funding scheme: ERC-ADG – Advanced Grant
Coordination: João F. Mano –  University of Aveiro

Engineered bone tissue has many advantages over natural bone grafts, including safety and limitless supply. However, current engineering methods cannot generate large vascularised grafts capable of in vivo integration and remodelling. To address this problem, the EU-funded REBORN project proposes to combine biomaterials based on proteins obtained from the amniotic membrane and cells from the umbilical cord to develop a 3D device capable of supporting bone tissue formation. Scientists will use hydrogels to provide geometrical, mechanical and topographic cues as well as bioactive soluble factors to drive cell differentiation and recreate the bone marrow niche.