InterLynk: Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair

InterLynk, a new research and innovation EU project, coordinated by the COMPASS Research Group, has just started with the aim to radically transform the design and fabrication of complex 3D biofunctional constructs for multi-tissue regeneration. Funded by the European Union’s Horizon 2020 programme, the InterLynk project gathers 8 European partners (Portugal, Germany, Netherlands and Italy), that include 4 universities, 1 research & technology organization and 4 SMEs, aiming to provide innovative regenerative solutions for the successful repair and regeneration of complex multi-tissue systems, in primis the temporomandibular joint. A transdisciplinary team with expertise in materials science, additive manufacturing systems, manufacturing process modelling, computational biomechanics, tissue engineering, biology and regenerative medicine, will collaborate in this ambitious 4-year project. InterLynk approach will, for the first time, synergistically address three key aspects related to the development of successful scaffolds for multi-tissue regeneration, providing: (i) new biomaterials able to construct a multimaterial scaffold, (ii) upgrade current manufacturing technologies to fabricate them and (iii) a multidimensional computational toolbox to model material properties, processing conditions and scaffold performance. InterLynk partners will develop a portfolio of biomaterials-based inks, all based on an innovative, highly bioactivity and biocompatible matrix made of human plasma-derivative platelet lysates, that can be patient-specific. The most advanced technologies will be engineered to develop 3D bioprinting processes able to combine different biomaterials in a single scaffold, with spatially control of their organization and distribution. Such will enable the fabrication of multimaterial 3D scaffolds mimicking the microenvironment interfaces needed to promote the regeneration of different tissues like bone, cartilage, ligament and tendon. With an overall budget of almost 6 million euros the InterLynk consortium will expand the frontiers of 3D printing, and personalized and regenerative medicine.